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Meng Lv, Yingjun Chang, Xiaojun Huang
《医学前沿(英文)》 2019年 第13卷 第1期 页码 45-56 doi: 10.1007/s11684-017-0595-7
关键词: haploidentical hematopoietic stem cell transplantation conditioning graft-versus-host disease relapse infection donor selection
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
《医学前沿(英文)》 2019年 第13卷 第2期 页码 238-249 doi: 10.1007/s11684-017-0599-3
关键词: interferon-α hematopoietic stem cell transplantation minimal residual disease donor lymphocyte infusion
《医学前沿(英文)》 2021年 第15卷 第5期 页码 728-739 doi: 10.1007/s11684-021-0833-x
关键词: second hematopoietic stem cell transplantation acute leukemia relapse chemotherapy modified donor lymphocyte infusion
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《医学前沿(英文)》 2013年 第7卷 第3期 页码 306-315 doi: 10.1007/s11684-013-0279-x
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options for hematological malignancies, and human leukocyte antigen-partially matched related donors (PMRDs) are a valuable option for HSCT. Several protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide. TCD including CD34+positive selection and CD3/CD19 depletion has successfully overcome the human leukocyte antigen disparity. However, TCD is associated with prolonged immune deficiencies, increased risks of infectious complications, and high transplantation-related mortality. PMRD HSCT without ex vivo TCD is well developed, and numerous patients have benefitted from it. Here, we review the literature on PMRD HSCT.
关键词: partially matched related donor hematopoietic stem cell transplantation allogeneic
供体来源的CD19靶向T细胞输注可以消除异基因造血干细胞移植后对供者淋巴细胞无反应的急性B淋巴细胞白血病微小残留病 Article
程翼飞, 陈育红, 闫晨华, 王昱, 赵翔宇, 陈瑶, 韩伟, 许兰平, 张晓辉, 刘开彦, 王莎莎, 张隆基, 肖磊, 黄晓军
《工程(英文)》 2019年 第5卷 第1期 页码 150-155 doi: 10.1016/j.eng.2018.12.006
白血病复发仍是异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)后急性B 淋巴细胞白血病(B cellHSCT 后治疗伴有MRD 的B-ALL 的主要方法是供者淋巴细胞输注(donor lymphoblastic infusion,DLI)。
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 153-163 doi: 10.1007/s11684-017-0548-1
To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo-SCT) and without showing any of the following events: poor graft function, grades II?IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3+ T cells, CD8+ T cells, and CD19+ B cells, and very slow in CD4+ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.
关键词: immune reconstitution hematopoietic stem cell transplantation event-free patients reference range
The influence of brain death on donor liver and the potential mechanisms of protective intervention
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 8-14 doi: 10.1007/s11684-011-0109-y
Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.
关键词: brain death donor liver
Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction
《化学科学与工程前沿(英文)》 2022年 第16卷 第12期 页码 1689-1699 doi: 10.1007/s11705-022-2186-7
关键词: direct coal liquefaction hydrogen-donor solvent induced pyrolysis radical mechanism density functional theory calculations
Factors influencing the somatic cell nuclear transfer efficiency in pigs
Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI
《农业科学与工程前沿(英文)》 2019年 第6卷 第1期 页码 73-80 doi: 10.15302/J-FASE-2018220
Using a data set from our laboratory, we assessed the effects of several factors on pig cloning efficiency. The results demonstrated that cells at high confluence (>90%) used as donor cell resulted in higher pregnancy rate, delivery rate and overall cloning efficiency (number of live offspring born per reconstructed embryo transferred to recipients) compared with the cells at 60% to 79% confluence and 80% to 89% confluence. Cells with four, five and six passages compromised the pregnancy and delivery rates compared with first passage cells. The number of blastocysts transferred by somatic cell nuclear transfer (SCNT) did not significantly affect the cloning efficiency, but transfer of blastocyst derived from culture 5 d after SCNT achieved a significantly higher pregnancy rate compared with one to two cell SCNT embryos from overnight culture. The highest pregnancy rate, delivery rate and the largest litter size were obtained when Bama Miniature pig fibroblasts were used as donor cells and Landrace/Yorkshire hybrid gilts were used as recipients. Recipients treated with chemicals for estrus synchronization had higher pregnancy rates compared with untreated recipients. Our data might be helpful for improving SCNT efficiency in pigs.
关键词: blastocyst donor cell estrus synchronization pregnancy rate pig cloning somatic cell nuclear transfer
Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide
《能源前沿(英文)》 doi: 10.1007/s11708-023-0910-8
关键词: polyimide (PI) film photoelectrochemistry band structure engineering aromatic unit
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
《医学前沿(英文)》 2019年 第13卷 第3期 页码 354-364 doi: 10.1007/s11684-018-0665-5
关键词: donor leukocyte infusion hematopoietic stem cell transplantation interferon-
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 1-7 doi: 10.1007/s11684-010-0105-7
Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques because of donor shortage. Reduced-size liver transplantation is based on Couinaud’s anatomical classification, benefiting children and small adult recipients but failing to relieve the overall donor shortage. Split liver transplantation provides chances to two or even more recipients when only one liver graft is available. The splitting technique must follow stricter anatomical and physiological criteria either ex situ or in situto ensure long-term quality. The first and most important issue involving living donor liver transplantation is donor safety. Before surgery, a series of donor evaluations—including anatomical, liver volume, and liver function evaluations—is indispensable, followed by ethnic agreement. At different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver transplantation, which employ piggyback techniques, are good alternatives. Partial liver transplantation enriches the practice and knowledge of the transplant society.
关键词: partial liver transplantation reduced-size liver transplantation split liver transplantation living donor liver transplantation
Acid Orange 7 degradation using methane as the sole carbon source and electron donor
《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1468-5
• AO7 degradation was coupled with anaerobic methane oxidation.
关键词: Azo dyes AO7 degradation Anaerobic methane oxidation Microbial community ANME-2d
“机械灌注+”应用于扩大标准供肝移植——肝尽其用 Review
王周城, Jack Martin, 余炯杰, 汪恺, Kourosh Saeb-Parsy, 徐骁
《工程(英文)》 2024年 第32卷 第1期 页码 30-41 doi: 10.1016/j.eng.2023.11.003
移植是终末期肝病最有效的治疗方法,但由于供体器官的短缺而受到限制。扩大标准供体(ECD)供肝在临床实践中越来越多地用于缓解这一挑战。然而,这些移植物耐受缺血的能力下降,危及冷保存期间器官的活力。机器灌注(MP)旨在改善器官保存并减少移植后并发症。然而,越来越明显的是,单独使用MP无法达到ECD供肝的最佳保存。因此,人们逐渐开始重视改良的 MP 策略,包括使用不同的灌注剂、改良的灌注方式并结合不同的治疗干预策略。本文中,我们提出了“机械灌注+”的新理念,代表这些旨在提升器官功能并可能实现ECD供肝体外再生的机械灌注新策略。为此,我们总结了现有和改良的MP策略,并阐述其在临床场景中修复不同ECD供肝的优势。
Reducing biliary complications in adult-to-adult living donor liver transplantation using right lobe
YAN Lunan, WEN Tianfu, WANG Wentao, YANG Jiayin, XU Mingqing, CHEN Zheyu, WU Hong
《医学前沿(英文)》 2008年 第2卷 第2期 页码 130-133 doi: 10.1007/s11684-008-0024-z
标题 作者 时间 类型 操作
Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoieticstem cell transplantation
Meng Lv, Yingjun Chang, Xiaojun Huang
期刊论文
leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donorlymphocyte infusion after allogeneic hematopoietic stem cell transplantation
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
期刊论文
used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor
期刊论文
Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation
null
期刊论文
供体来源的CD19靶向T细胞输注可以消除异基因造血干细胞移植后对供者淋巴细胞无反应的急性B淋巴细胞白血病微小残留病
程翼飞, 陈育红, 闫晨华, 王昱, 赵翔宇, 陈瑶, 韩伟, 许兰平, 张晓辉, 刘开彦, 王莎莎, 张隆基, 肖磊, 黄晓军
期刊论文
patients receiving haploidentical allografts and those receiving human leukocyte antigen-matched sibling donor
null
期刊论文
The influence of brain death on donor liver and the potential mechanisms of protective intervention
null
期刊论文
Factors influencing the somatic cell nuclear transfer efficiency in pigs
Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI
期刊论文
disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell
Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang
期刊论文